PhD candidate to study the relationship between protein folding and metal-binding. Project description The presence of a metal ion is critical for a multitude of proteins to function. Such functions are diverse, from signaling, to catalysis, and sensing. One way to mimic and potentially emulate such proteins is to design metal-binding proteins from scratch. A fundamental aim of this field of de novo metalloprotein design is understanding how protein folding and metal-binding affect one another. This relationship can, in turn, affect the function of such proteins. The aim of this project is to uncover the effects of protein folding on metal-binding and vice versa using helical protein scaffolds. The PhD candidate will design and synthesize a range of metal-binding peptides and proteins using solid-phase peptide synthesis and bacterial protein expression techniques. The metal-binding abilities of the resulting proteins will be quantified and their structures will be characterized in the presence and absence of metals in order to unravel the basis of this complex relationship. Our organisation The Faculty of Science is a world-class faculty where staff and students work together in a dynamic international environment.
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TNO cooperates with companies, the public sector and other organisations, to apply our knowledge and expertise with and for others. TNO offers you the chance to do groundbreaking work and help customers and society with innovative, practical and smart solutions. On TNO Insights you can read in-depth interviews and articles. TNO and the Zuiderzeeland Water Board, in collaboration with partners, have started the construction Read more future view Privacy-friendly data technology expands oncology research opportunities 30 July Privacy-friendly data helps oncology research opportunities to give insights about more successful treatment Read more future view Reliable and affordable energy supply in TNO answers questions 27 July A reliable and affordable energy supply in what will it entail?
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AMCS integrates solutions for all processes which are required in your company in a perfect way. Standard modules are supplemented with customer-specific applications to make your organization complete. Data which is always up-to-date, and the right tools to analyze it, provide you with the information which you need to be successful in the market, in the operation of the business as well as on the financial side of it. Through this AMCS guarantees an effective control and transparency of your business transactions.
You can also use the application for quotes. The contract position is updated in real time providing vital information in the metal business. Position cannot only be controlled by a group of metals or commodity but also on a contract level in trading activities. The software answers your question whether you are long or short on a large contract, are you over a pre-defined risk limit, what is priced and what has to be fixed still.
This information can automatically be brought to the attention of the responsible trader through our CRM system. In regard to foreign currency, the software has the options to fix currency rates by contract, or link foreign currency deals with a physical contract. This reduces risk, provides correct results, and easy reconciliation. The flexible pricing management allows for the very frequent price modifications in the recycling business.
Prices are based on a multitude of criteria; commodities, customers, customer groups, customer locations, date range, quantities, price codes or sites.
Nightwish is a symphonic metal band from Kitee , Finland. The band was formed in by lead songwriter and keyboardist Tuomas Holopainen , guitarist Emppu Vuorinen , and former lead singer Tarja Turunen. Although Nightwish have been prominent in their home country since Angels Fall First , they did not achieve wider success until the release of the albums Oceanborn , Wishmaster and Century Child Their album, Once , has sold more than one million copies  and was the band’s breakthrough in the United States.
After the concert, the other members informed Turunen with an open letter that she was no longer a member of Nightwish. The album’s lead single, ” Amaranth “, became one of Nightwish’s most successful in Europe.
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We recycle ferro and non-ferro materials. So we keep valuable raw materials in the chain. Every year we process around , tons of material, originating from collectors, scrap companies and metalworking industries throughout Western Europe. Jansen optimises the value of your scrap and offers custom logistical solutions.
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The global shift away from fossil fuels presents us with an opportunity. In redesigning systems to mitigate climate change, we have a chance to rethink the way we interact with natural resources as a whole, and prioritise systems that improve the quality of human life. Renewable energy is critical to a more sustainable and circular economy. However, the effective transition to greener energy will also require a circular economy for critical metals. This is the first report in a series of studies on the metal demand for our new, carbon-free economy.
It is followed by a study on the critical metal demand for electromobility in batteries and electric vehicles. The aim of these studies is to understand the new dependencies arising from a carbon-free economy, and what we can do to move, rapidly and safely, towards this new economy with both societal needs and critical raw materials in mind. In , signatories of the Paris Agreement agreed on measures to limit global warming to a maximum of 2 degrees Celsius.
The national contribution of the Netherlands in this regard is currently being determined within the Dutch Klimaatakkoord hereafter: Climate Agreement. This agreement stipulates an increase in the production of renewable energy, of which a large share is renewable electricity produced by solar panels and wind turbines.
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