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PhD candidate to study the relationship between protein folding and metal-binding. Project description The presence of a metal ion is critical for a multitude of proteins to function. Such functions are diverse, from signaling, to catalysis, and sensing. One way to mimic and potentially emulate such proteins is to design metal-binding proteins from scratch. A fundamental aim of this field of de novo metalloprotein design is understanding how protein folding and metal-binding affect one another. This relationship can, in turn, affect the function of such proteins. The aim of this project is to uncover the effects of protein folding on metal-binding and vice versa using helical protein scaffolds. The PhD candidate will design and synthesize a range of metal-binding peptides and proteins using solid-phase peptide synthesis and bacterial protein expression techniques. The metal-binding abilities of the resulting proteins will be quantified and their structures will be characterized in the presence and absence of metals in order to unravel the basis of this complex relationship. Our organisation The Faculty of Science is a world-class faculty where staff and students work together in a dynamic international environment.

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PhD defense: Niobia-Supported Metal Catalysts for Synthesis Gas Conversion

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Nightwish is a symphonic metal band from Kitee , Finland. The band was formed in by lead songwriter and keyboardist Tuomas Holopainen , guitarist Emppu Vuorinen , and former lead singer Tarja Turunen. Although Nightwish have been prominent in their home country since Angels Fall First , they did not achieve wider success until the release of the albums Oceanborn , Wishmaster and Century Child Their album, Once , has sold more than one million copies [3] and was the band’s breakthrough in the United States.

After the concert, the other members informed Turunen with an open letter that she was no longer a member of Nightwish. The album’s lead single, ” Amaranth “, became one of Nightwish’s most successful in Europe.

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PhD candidate to study the relationship between protein folding and metal-binding

We recycle ferro and non-ferro materials. So we keep valuable raw materials in the chain. Every year we process around , tons of material, originating from collectors, scrap companies and metalworking industries throughout Western Europe. Jansen optimises the value of your scrap and offers custom logistical solutions.

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The global shift away from fossil fuels presents us with an opportunity. In redesigning systems to mitigate climate change, we have a chance to rethink the way we interact with natural resources as a whole, and prioritise systems that improve the quality of human life. Renewable energy is critical to a more sustainable and circular economy. However, the effective transition to greener energy will also require a circular economy for critical metals. This is the first report in a series of studies on the metal demand for our new, carbon-free economy.

It is followed by a study on the critical metal demand for electromobility in batteries and electric vehicles. The aim of these studies is to understand the new dependencies arising from a carbon-free economy, and what we can do to move, rapidly and safely, towards this new economy with both societal needs and critical raw materials in mind. In , signatories of the Paris Agreement agreed on measures to limit global warming to a maximum of 2 degrees Celsius.

The national contribution of the Netherlands in this regard is currently being determined within the Dutch Klimaatakkoord hereafter: Climate Agreement. This agreement stipulates an increase in the production of renewable energy, of which a large share is renewable electricity produced by solar panels and wind turbines.

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